New evidence also suggests that Cox-2 inhibitors such as Bextra, Celebrex and the now-withdrawn Vioxx may delay or otherwise interfere with ovulation. Therefore, those who are trying to conceive should avoid use of these drugs, except during menses.

Other NSAID pain relievers includes ibuprofen (Advil) and naproxen (Aleve). While there is no specific data yet that either of these two NSAIDs interfere with ovulation, it may be prudent to limit your use of them during your midcycle fertile period as well, especially if you have been having any difficulty conceiving. We recommend acetominophen (Tylenol) for pain relief for those who are trying to conceive.